• High-resolution atomic force microscope on an inverted optical microscope allows simultaneous AFM and fluorescence imaging
• Top-down scanner design enables effortless setup
• Inverted optical view, open-top viewing access, and top illumination provide superior optical contrast
• Rigid stage mounting provides low noise floor for sub-nanometer resolution
• Patented MAC Mode option provides gentlest, nondestructive AFM imaging of samples in fluid
• PicoTREC option delivers real-time, simultaneous topography and recognition imaging
• Sample-handling plates available to facilitate easy imaging in fluids or ambient air
• Easy Quick Slide sample-loading mechanism makes sample preparation simple

Keysight’s 7500 inverted light microscope (ILM) system combines the power of a high-resolution atomic force microscope (AFM) with the direct optical viewing capability of an inverted optical microscope.

The Keysight ILM offers unparalleled performance and ease of use for imaging in fluids. It extends AFM utility in order to encompass studies of single molecules, polymers, cell membranes, whole cells, and much more. Atomic force and optical (or fluorescence) microscopy data can be obtained simultaneously with the Keysight ILM.

The rigid stage structure provides the low noise floor needed to obtain sub-nanometer resolution. Furthermore, the advanced design allows the AFM to sit on top of an inverted microscope and under the illumination pillar, resulting in better optical contrast for the images.

Keysight’s QuickSlide sample-loading mechanism and a flexible sample-handling plate makes sample preparation easy. The AFM is mounted on the QuickSlide assembly, allowing the user to change samples and/or solutions without affecting the alignment of the AFM or the optical microscope.